En respuesta a la pandemia actual del COVID-19 (Coronavirus), el equipo del estudio ANCHOR ha aconsejado al personal local a que se comunique con los participantes del estudio que ya tienen cita programada durante las próximas 4 semanas para determinar si uno debe acudir a la clínica, o no. Si no recibes noticia del personal clínico de tu local, favor de contactarlos. Si estás en espera de la visita de evaluación, te agradecemos tu paciencia. Sí te atenderemos tan pronto como sea posible, una vez que sea seguro hacerlo. Mientras tanto, puedes comunicarte con tu clínica local del estudio ANCHOR si tienes alguna duda o inquietud.
Prevalence of anal human papillomavirus infection and anal HPV-related disorders in women: a systematic review
September 29, 2015
The aim of this study was to systematically review the findings of publications addressing the epidemiology of anal human papillomavirus (HPV) infection, anal intraepithelial neoplasia, and anal cancer in women. We conducted a systematic review among publications published from Jan. 1, 1997, to Sept. 30, 2013, to limit to publications from the combined antiretroviral therapy era. Three searches were performed of the National Library of Medicine PubMed database using the following search terms: women and anal HPV, women anal intraepithelial neoplasia, and women and anal cancer. Publications were included in the review if they addressed any of the following outcomes: (1) prev- alence, incidence, or clearance of anal HPV infection, (2) prevalence of anal cytological or histological neoplastic abnormalities, or (3) incidence or risk of anal cancer. Thirty-seven publications addressing anal HPV infection and anal cytology remained after applying selection criteria, and 23 anal cancer publications met the selection criteria. Among HIV- positive women, the prevalence of high-risk (HR)eHPV in the anus was 16e85%. Among HIV-negative women, the prevalence of anal HR-HPV infection ranged from 4% to 86%. The prevalence of anal HR-HPV in HIV-negative women with HPV-related pathology of the vulva, vagina, and cervix compared with women with no known HPV-related pathology, varied from 23% to 86% and from 5% to 22%, respectively. Histological anal high-grade squamous intraepithelial lesions (anal intraepithelial neoplasia 2 or greater) was found in 3e26% of the women living with HIV, 0e9% among women with lower genital tract pathology, and 0e3% for women who are HIV negative without known lower genital tract pathology. The incidence of anal cancer among HIV-infected women ranged from 3.9 to 30 per 100,000. Among women with a history of cervical cancer or cervical intraepithelial neoplasia 3, the incidence rates of anal cancer ranged from 0.8 to 63.8 per 100,000 person-years, and in the general population, the incidence rates ranged from 0.55 to 2.4 per 100,000 person-years. This review provides evidence that anal HPV infection and dysplasia are common in women, especially in those who are HIV positive or have a history of HPV-related lower genital tract pathology. The incidence of anal cancer continues to grow in all women, especially those living with HIV, despite the widespread use of combined antiretroviral therapy.