Please continue to come in for study visits. By participating, you can continue to help advance this research and improve people’s lives, in addition to taking care of your own health. Now that we know that treatment can help prevent anal cancer, we strongly recommend that everyone get treatment. We are still collecting data to answer questions about who needs HRA and treatment, and which anal HSIL lesions are more likely to progress to cancer. Study follow-up will continue until September 30, 2024